The use of beta blockers in septic shock
DOI:
https://doi.org/10.62486/agmu202558Keywords:
Beta-blockers, Sepsis, Septic ShockAbstract
Introduction: the mortality rate in septic patients or septic shock is still very high. Beta-blockers can reduce an overstimulation of adrenergic receptors in septic patients or in septic shock treated in ICU.
Objective: to analyze the usefulness of the use of beta-blockers in septic shock.
Method: a synthesis of available materials on the use of beta-blockers in septic patients and septic shock was performed for a review of the literature. Available articles reporting cases of treatment of this entity were included. For this purpose, information was searched using keywords.
Results: septic shock is a clinical entity that requires rapid action by health teams. It triggers effects at all levels of the economy; however, the management of the cardiovascular system is essential for the reestablishment of the normal functioning of the organism, hence drugs with an effect on the cardiovascular system are highly analyzed.
Conclusions: the literature suggests that the use of beta-blockers in patients with septic shock may be useful; however, it is necessary to study the available scientific evidence from a systematic approach, as well as to carry out clinical trials
References
Vela-Vásquez RS, Grigorov-Tzenkov I, Aguilar JL. Bloqueadores beta en shock séptico: una revisión. Revista Española de Anestesiología y Reanimación. 2015; 62(2). https://doi.org/10.1016/j.redar.2014.07.003. DOI: https://doi.org/10.1016/j.redar.2014.07.003
Entropía aproximada de la frecuencia cardíaca para el diagnóstico precoz de sepsis en adultos internados en terapia intensiva. Rev Fac Cien Med Univ Nac Cordoba. 2023;80. https://revistas.unc.edu.ar/index.php/med/article/view/42828
Espinoza Villafuerte MV, Martínez Zubieta R, Zaragoza Galván JJ. Relación entre consumo crónico de betabloqueadores y mortalidad en sepsis y choque séptico. Med. crít. (Col. Mex. Med. Crít.). 2017; 31( 2 ): 74-77. http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2448-89092017000200074&lng=es.
Cruz MC, Reis L. Betabloqueadores no choque séptico: já chegamos lá?. Rev bras ter intensiva. 2017; 29(1):1–3. https://doi.org/10.5935/0103-507X.20170001 DOI: https://doi.org/10.5935/0103-507X.20170001
Efeito paradoxal do antagonismo alfa-1 adrenérgico na disfunção vascular da sepse. Disponible en: https://repositorio.ufsc.br/handle/123 456789/193209
Hasegawa D, Sato R, Prasitlumkum N, Nishida K, Takahashi K, Yatabe T, Nishida O. Effect of Ultrashort-Acting β-Blockers on Mortality in Patients With Sepsis With Persistent Tachycardia Despite Initial Resuscitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Chest. 2021; 159(6):2289-2300. doi: 10.1016/j.chest.2021.01.009 DOI: https://doi.org/10.1016/j.chest.2021.01.009
Landiolol: pharmacology and its use for rate control in atrial fibrillation in an emergency setting. Disponible en: https://cima.aemps.es/cima/dochtml/ft/89271/FT_89271.html
Vadmecum Esmolol. Disponible en: https://www.vademecum.es/principiosactivos-esmolol-c07ab09-us
Reed EB, Tarver H. The influence of diet on the lipogenic response to thyroxine in rat liver. Life Sci. 1975 Dec 15;17(12):1785-97. https://pubmed.ncbi.nlm.nih.gov/3705 6709/ DOI: https://doi.org/10.1016/0024-3205(75)90461-0
Sanfilippo F, Santonocito C, Morelli A, Foex P. Beta-blocker use in severe sepsis and septic shock: a systematic review. Curr Med Res Opin. 2015;31(10):1817-25. doi: 10.1185/03007995.2015.1062357. DOI: https://doi.org/10.1185/03007995.2015.1062357
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Copyright (c) 2025 Nathalia Dornellas Sant’Anna, Anibal Danilo Farias (Author)
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